The Bible has a lot to say about anxiety, but the word itself may not be found all that often. In the English Standard Version, it is used 8 times. In the New International Version, it is found 7 times. The King James Version does not use the word at all. Synonyms like trouble, heaviness, distress, and cares are used in its place.
The specific causes of anxiety are probably more than can be enumerated, but a few examples from the Bible point to some general causes. In Genesis 32, Jacob is returning home after many years away. One of the reasons he had left home was to escape the anger of his brother, Esau, from whom Jacob had stolen the birthright and blessing from their father. Now, as Jacob nears his homeland, he hears that Esau is coming to meet him with 400 men. Jacob is immediately anxious, expecting a horrible battle with his brother. In this case, the anxiety is caused by a broken relationship and a guilty conscience.
In 1 Samuel 1, Hannah is distressed because she was unable to conceive children and she was being taunted by Peninnah, her husband’s other wife. Her distress is caused by unfulfilled desires and the harassment of a rival.
In Esther 4, the Jewish people are anxious because of a royal decree allowing them to be massacred. Queen Esther is anxious because she was planning to risk her life on behalf of her people. Fear of death and the unknown is a key element of anxiety.
Not all anxiety is sinful. In 1 Corinthians 7:32, Paul states that an unmarried man is “anxious” about pleasing the Lord, while a married man is “anxious” about pleasing his wife (ESV). In this case, the anxiety isn’t a sinful fear but a deep, proper concern.
Probably the best-known passage on anxiety comes from the Sermon on the Mount in Matthew 6. Our Lord warns us against being anxious about the various cares of this life. For the child of God, even necessities like food and clothing are nothing to worry about. Using examples from God’s creation, Jesus teaches that our Heavenly Father knows our needs and cares about them. If God takes care of simple things like grass, flowers, and birds, won’t He also care for people who are created in His image? Rather than worry over things we cannot control, we should “seek first the kingdom of God and his righteousness, and all these things [the necessities of life] will be added to you” (verse 33). Putting God first is a cure for anxiety.
Many times, anxiety or concern is a result of sin, and the cure is to deal with the sin. Psalm 32:1–5 says that the person whose sin is forgiven is blessed, and the heavy weight of guilt is taken away when sins are confessed. Is a broken relationship creating anxiety? Try to make peace (2 Corinthians 13:11). Is fear of the unknown leading to anxiety? Turn the situation over to the God who knows everything and is in control of it all (Psalm 68:20). Are overwhelming circumstances causing anxiety? Have faith in God. When the disciples became distressed in a storm, Jesus first rebuked their lack of faith, then rebuked the wind and the waves (Matthew 8:23–27). As long as we are with Jesus, there is nothing to fear.
We can count on the Lord to provide for our needs, protect us from evil, guide us, and keep our souls secure for eternity. We may not be able to prevent anxious thoughts from entering our minds, but we can practice the right response. Philippians 4:6, 7 instructs us to “not be anxious about anything, but in everything by prayer and supplication with thanksgiving let your requests be made known unto God. And the peace of God, which surpasses all understanding, will guard your hearts and your minds in Christ Jesus.”
 Got Questions Ministries. (2010). Got Questions? Bible Questions Answered. Bellingham, WA: Logos Bible Software.