16:10 — For You will not leave my soul in Sheol, nor will You allow Your Holy One to see corruption.
This verse is an important prophecy about the resurrection of Jesus Christ, quoted by Peter in Acts 2:27. Peter argued that since David had died and his body decayed, the verse had to apply to the Messiah, Jesus.
16:10 These words expressed the confidence of the lesser David, but were applied messianically to the resurrection of the Greater David (the Lord Jesus Christ) both by Peter (Ac 2:25–28) and Paul (Ac 13:35).
16:10 In Acts, both Peter and Paul apply this passage to Jesus as a prophecy of His resurrection (Acts 2:24–36; 13:34–39).
16:10 you will not abandon my soul to Sheol. The immediate application of this psalm is to David and to the Old Testament saints. It refers to deliverance from the immediate threat of death, but it points prophetically to the Son of David whom the historical David reflected and anticipated. Both Peter and Paul recognized that Jesus was the ultimate fulfillment of this psalm (Acts 2:25–28; 13:35).
16:10 David was confident of his deliverance from Sheol and “the Pit”; that is, from death. The Lord will protect his faithful worshiper from it. In its Israelite application, the context could be the struggle against the adherents of false religions, “those who take another god” (v. 4). Still occupying enclaves within Canaan, these peoples ignored the “boundary lines” (v. 6) by which the Lord allocated the promised land to the tribes of Israel (Jos 13–17). Opposition from these polytheistic groups often took the form of open warfare, endangering the king’s life. But the psalm has a prophetic application to the coming King, the Messiah (“Faithful One”). At Pentecost, Peter quoted these words with reference to the resurrection of Jesus (Acts 2:8–31); Paul used the psalm the same way in a sermon at Antioch in Pisidia (Acts 13:25). If David’s words stopped short of affirming a bodily resurrection, they were certainly consistent with that hope. Because Christian believers participate in Jesus’ resurrection (e.g., Rm 6:4, 8; 8:29; Col 3:1; Rv 1:5), the words of the psalm apply to the “faithful ones” of all ages—we will not be abandoned to the decay of the grave.
 Stanley, C. F. (2005). The Charles F. Stanley life principles Bible: New King James Version (Ps 16:10). Nashville, TN: Nelson Bibles.
 MacArthur, J. F., Jr. (2006). The MacArthur study Bible: New American Standard Bible. (Ps 16:10). Nashville, TN: Thomas Nelson Publishers.
 Sproul, R. C. (Ed.). (2005). The Reformation Study Bible: English Standard Version (p. 748). Orlando, FL; Lake Mary, FL: Ligonier Ministries.
 Cabal, T., Brand, C. O., Clendenen, E. R., Copan, P., Moreland, J. P., & Powell, D. (2007). The Apologetics Study Bible: Real Questions, Straight Answers, Stronger Faith (p. 802). Nashville, TN: Holman Bible Publishers.