Tears and tear-producers (21:4)
There will also be no tears in heaven because ‘God will wipe away every tear from their eyes’ (21:4). The reason there will be no tears in heaven is because the tear-producers—death, sorrow and pain—will all be for ever gone (v. 4).
Death will have died, and all the things associated with death—hospitals, funeral homes, cemeteries, obituary columns—will no longer exist. All sorrow will have vanished. No one in heaven will be broken-hearted or in anguish. Pain will also have no place there. Nothing will hurt in heaven!
There will be no night in heaven (21:25; 22:5). The night, which we associate with sin, will no longer exist.
4. “And he will wipe away every tear from their eyes, and there will no longer be death, or grief, or crying, nor will there be pain anymore, because the first things passed away.”
This is now the second time (7:17) that John alludes to Isaiah 25:8 (see Jer. 31:16), “The Sovereign Lord will wipe away the tears from all faces.” Like a mother who bends down and tenderly wipes away the tears from the eyes of her weeping child, so the Lord God stoops down to dry the tear-filled eyes of his children. Here is a telling portrait of God’s tender mercies extended to the suffering members of his household. Ever since the fall into sin, mankind has shed countless tears, so that this present world indeed can be called a vale of tears. The shedding of tears is the result of anguish, oppression, persecution, sorrow, and death.
Death rules supreme until the final judgment (20:14). But that power will have effectively come to an end when God and his people are together. Jewish literature also states that at the time of the Messiah death will cease forever. With the departure of death, mourning, crying, and disease also disappear, for all these have been caused by the curse of sin affecting God’s creation (Gen. 2:17; Rom. 8:20–23). None of them have any part in God’s renewed creation, which is marked by peace and harmony, joy and mirth, pleasure and delight (Isa. 35:10; 51:11; 65:19). Indeed the first things have passed away and all things are new (Isa. 43:18; 65:17).
Ver. 4. God shall wipe away, etc.—See Ps. 126:5, 6; Is. 25:8; 65:19.—Death.—See ch. 20:14.—Sorrow.—Mourning for the dead, especially.—Nor crying, nor pain.—Κραυγή is the acute form of sorrow (“vehement outcry,—for instance, at the experience of such acts of violence as are indicated in ch. 13:10, 17; 2:10. [Bleek, Ewald; comp. Ex. 3:7, 9; Esther 4:3.]” Duesterd.). The πόνος, pain, or painful labor, is the chronic form of the same.—For the first things.—To be taken in an emphatic sense, like the first man (1 Cor. 15:4, 5 sqq.)—the present æon. In accordance with the entire mass of Holy Scripture, the world is designed to be a succession of two worlds.
21:4 wipe away every tear. Since there will never be a tear in heaven, nothing will be sad, disappointing, deficient, or wrong (cf. Is 53:4, 5; 1Co 15:54–57).
21:4 By wiping away every tear and eliminating death, mourning, and pain (Isa. 25:8; 65:19–20), God will reverse the curse that entered the world through human sin.
21:4 wipe away every tear from their eyes God will extinguish all sorrow and grief (Rev 7:17).
 MacArthur, J. F., Jr. (2006). The MacArthur study Bible: New American Standard Bible. (Re 21:4). Nashville, TN: Thomas Nelson Publishers.