22 Out of the confidence that God is enthroned (v. 19), the psalmist encourages the godly to reflect on his justice. In contrast to human treachery, Yahweh will “sustain” the righteous so that they will not be overcome (cf. 37:23–24). The oracle of salvation encourages the godly to “cast” their “cares” (lit., “what he has given you”; cf. 1 Pe 5:7) on the Lord. For a similar expression see 37:5–7. Calvin, 3:344, after struggling with this text, wrote the following:
It is not enough that we make application to God for the supply of our wants. Our desires and petitions must be offered up with a due reliance upon his providence, for how many are there who pray in a clamorous spirit, and who, by the inordinate anxiety and restlessness which they evince, seem resolved to dictate terms to the Almighty … and there can be no question that the only means of checking an excessive impatience is an absolute submission to the Divine will, as to the blessings which should be bestowed.
22 The one praying now offers advice directly to the audience, but not about being betrayed by a friend. Again an abrupt shift in thinking takes the audience by surprise. The speaker is now back to assurance and the certainty that God will sustain and not let the righteous fall. One wonders if the assurance is really for the audience, or is it another way of convincing the soul that God’s promises are sure? It is the heart of what the person crying out to God is depending on—it is a wish expressed as an affirmation.
22 Cast thy burden upon the Lord, and he shall sustain thee: he shall never suffer the righteous to be moved.
- “Thy burden,” or what thy God lays upon thee, lay thou it “upon the Lord.” His wisdom casts it on thee, it is thy wisdom to cast it on him. He cast thy lot for thee, cast thy lot on him. He gives thee thy portion of suffering, accept it with cheerful resignation, and then take it back to him by thine assured confidence. “He shall sustain thee.” Thy bread shall be given thee, thy waters shall be sure. Abundant nourishment shall fit thee to bear all thy labours and trials. As thy days so shall thy strength be. “He shall never suffer the righteous to be moved.” He may move like the boughs of a tree in the tempest, but he shall never be moved like a tree torn up by the roots. He stands firm who stands in God. Many would destroy the saints, but God has not suffered it, and never will. Like pillars, the godly stand immovable, to the glory of the Great Architect.
55:22 The golden peak of Psalm 55 is reached in verse 22:
Cast your burden on the Lord,
And He shall sustain you;
He shall never permit
the righteous to be moved.
The psalmist came to realize that the best course in time of troubles is not to run away from them, but to cast the burden of them on the Lord. May we learn the lovely lesson set forth by Bishop Horne: “He who once bore the burden of our sins and sorrows requests that we should now and ever permit Him to bear the burden of our cares.”
55:22 Cast your burden upon the Lord. The word for “burden” implies one’s circumstances, one’s lot. The psalmist promises that the Lord will uphold the believer in the struggles of life.
55:22 Cast your burden. The Septuagint renders this “cast your anxieties,” and 1 Pet. 5:7 urges Christians to a similar faith in the face of persecution. moved. 
55:22 he will never permit the righteous to be moved. The context of the psalm shows that there is no unqualified promise that the righteous will always be happy and prosperous. The psalmist sings this lament to the Lord because he is in despair. The verse must mean that God will not leave the righteous in the fallen position forever, but will vindicate them in the end.
 deClaissé-Walford, N., & Tanner, B. (2014). Book Two of the Psalter: Psalms 42–72. In E. J. Young, R. K. Harrison, & R. L. Hubbard Jr. (Eds.), The Book of Psalms (p. 478). Grand Rapids, MI; Cambridge, U.K.: William B. Eerdmans Publishing Company.
 MacDonald, W. (1995). Believer’s Bible Commentary: Old and New Testaments. (A. Farstad, Ed.) (pp. 634–635). Nashville: Thomas Nelson.
 MacArthur, J. F., Jr. (2006). The MacArthur study Bible: New American Standard Bible. (Ps 55:22). Nashville, TN: Thomas Nelson Publishers.
 Sproul, R. C. (Ed.). (2005). The Reformation Study Bible: English Standard Version (p. 784). Orlando, FL; Lake Mary, FL: Ligonier Ministries.