22. The negatives used in this verse are emphatic, indicating permanent prohibitions. Do not bring out a load out of your houses. Part of the houses of craftsmen would be given over to their workshop. They would bring out into the street, or carry to the local market, items they wished to sell. ‘Do not’ do any work on the Sabbath is a citation from the Decalogue (Exod. 20:10; Deut. 5:14), as also is the following:
But keep the Sabbath day holy. By keeping it holy (<√qādaš, 1:5; 6:4) was meant setting it apart for the service of the Lord as a day sacred to him (Exod. 20:10; 31:5; 35:2; Lev. 24:8). This had been clearly set out at Sinai as I commanded your forefathers (cf. 11:4), and so the practice was one of longstanding and basic to the covenant constitution. As such, the people ought to have been careful to give attention to it. The reference to the Lord ‘commanding’ Sabbath observance may indicate that it is the form of the commandments found in Deuteronomy that lies behind this statement. Unlike Exodus, Deut. 5:12 has the phrase ‘as the Lord your God has commanded you’ and Deut. 5:15 ends, ‘Therefore the Lord your God has commanded you to observe the Sabbath day.’ The use of ‘command’ may relate to the need for direct revelation before the nature of this observance is obvious to fallen mankind.
Ver. 22. But hallow ye the Sabbath day.—Cheating God out of Sunday:—
An old Christian, living at Salem, was much annoyed by the conduct of some of his neighbours who persisted in working on the Sabbath. One Sabbath, as he was going to Church, his Sabbath-breaking neighbours called out to him sneeringly from the hayfield, “Well, father, we have cheated the Lord out of two Sundays anyway!” “I don’t know that,” replied the old gentleman, “I don’t know; the account is not yet settled.”
The design of the Sabbath:—
The true spirit of the Sabbath appointment is, not that we should condense the religion of the week into the Sabbath, but that we should carry forth from the Sabbath its hallowed impulses and feelings into the other days of the week, to elevate and sustain us amid its wearisome secularities and depressing cares. The Lord has given us the Sabbath, not to relieve us of out religion, but so to revive our religion on that day as to impel its healthy tide into the remotest nook and corner of everyday duty. (Andrew Thomson.)
 Mackay, J. L. (2004). Jeremiah: An Introduction and Commentary: Chapters 1–20 (Vol. 1, pp. 526–527). Fearn, Ross-shire, Scotland: Mentor.