They should seek the Lord, in the hope that they might grope for Him and find Him, though He is not far from each one of us.
There is a fundamental emptiness in every human being which can only be filled by the presence of God Himself. It is interesting to note that the only time Jesus Christ cried out in loneliness was from the cross when the Father forsook Him and allowed Him to die as a sacrifice for the world.
Without the presence of God, the most agonizing loneliness will afflict even the strongest person. No person should search for a solution for his loneliness without solving the basic issue of separation from God.
Accepting Jesus Christ, and being filled by His Spirit, is the first step toward overcoming the negative dimensions of loneliness.
 Jeremiah, D. (2002). Sanctuary: finding moments of refuge in the presence of God (p. 291). Nashville, TN: Integrity Publishers.